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The NIA Genetics Initiative/NIA-AD FBS/LOAD Study is a multi-site study initiated in 2002 with the purpose of identifying families with multiple members diagnosed with late-onset Alzheimer’s Disease (LOAD). Autopsy is offered to all active study subjects.

Study Participants

The study requires at least two full siblings with Alzheimer’s disease or a related dementia and a third family member who is either: 1) affected and over age 50; or 2) unaffected and over age 60. In addition, a control cohort was also enrolled. These subjects were enrolled over the age of 60 with no neurological problems such as Alzheimer’s disease, Parkinson’s disease or stroke and have no parents, children or siblings with Alzheimer’s disease.

Available Data

Enrolled family members complete a study visit (in person or by telephone).

Study subjects are followed longitudinally and complete a study visit approximately every 1-2 years.

The catalog for the NIA-AD FBS Study consists of a subset of variables that can be used to better understand the dataset and perform initial feasibility studies. Sites submit study data quarterly to the study data coordinating center located at Columbia University. This catalog is then updated quarterly after data cleaning is complete. Additional data can be requested from Columbia University:

LOAD Data Request/Manuscript Proposal

Available Biospecimens

Genomic DNA, Cell Line DNA, Lymphoblastoid Cell Lines (LCLs), Plasma, PBMCs

Introduction to NCRAD iPSC Initiative, Online Catalog, and Application Process
Watch this video to learn more about the NCRAD iPSC Initiative, online catalog, and application process.